Breast Cancer Drug More Effective In The Presence Of CK8 And CK18 (redOrbit)

Image Caption: The figures show that fulvestrant-mediated cytoplasmic localization of ER is associated with intermediate filament proteins CK8 and CK18. After treatment of MCF-7 and T47D cells (breast cancer cells) with fulvestrant, dramatic cytoplasmic localization of ER was observed. The results indicate that the presence of CK8 and CK18 is necessary for fulvestrant-induced cytoplasmic ...

10 Mar 2010, 2:16 pm | click here to view more